Undergraduate degree: B.Sc. in Biochemistry

    Colorado State University 1992

 

Post graduate degree: Ph.D in Physiology and Biophysics 2007

                                       University of Illinois at Chicago

                                       R. John Solaro, Advisor

 

Google Scholar Link

 

Lab Project(s):

1. Role of nuclear alpha1-adrenergic receptors in cardiac myocyte contractility.

2. Effects of nitrosylation of cardiac myofilaments.

3. Role of protein kinase C isoforms in myocyte contractility and survival.

 

Random tidbit: Richard Nixon and I share the same birthday, but not the same ethics.

 

Publications:

• Zhang L, Guo J, Zhang P, Xiong Q, Wu SC, Xia L, Roy SS, Tolar J, O'Connell TD, Kyba M, Liao K, and Zhang J. 2015. Derivation and high engraftment of patient-specific cardiomyocyte-sheet using induced pluripotent stem cells generated from adult cardiac fibroblast. Circ Heart Fail. PMID: 25420485.

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• Eclov, JA, Qian Q, Redetke R, Chen Q, Wu SC, Healy CL, Ortmeier SB, Harmon E, Shearer GC, and O'Connell TD. 2015. EPA, not DHA, prevents fibrosis in pressure overload induced heart failure; potential role of free fatty acid receptor 4. J Lipid Res. PMID: 26435012.

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• Wu SC, and O'Connell TD. 2014. A nuclear option? G-protein coupled receptors at the nucleus in cardiac myocytes.  J Cardiovasc Pharmacol. PMID: 25551323.

 

• Wu SC, and O'Connell TD. 2014. Nuclear Compartmentalization of α1-Adrenergic Receptor Signaling in Adult Cardiac Myocytes. J Cardiovasc Pharmacol. PMID: 25264754.

 

• Wu SC, Dahl EF, Wright CD, Cypher AL, Healy CL, O’Connell TD. ­­Nuclear Localization of α1A-Adrenergic Receptors is Required for Signaling in Cardiac Myocytes: An “inside-out” α1-AR signaling pathway. J American Heart Association 3(2):e000145, 2014. 

 

• Wright CD†, Wu SC†, Dahl EF, Sazama AJ, O'Connell TD. Nuclear localization drives α1-adrenergic receptor oligomerization and signaling in cardiac myocytes. Cell Signal 24(3): 794-802, 2012. †Equal contribution. 

 

• Chen Q, Williams R, Healy CL, Wright CD, Wu SC, O’Connell TD. Induction of specific gene expression programs following myocardial infarction correlates with better survival in female mice. J Mol Cell Cardiol 49(5):801-1, 2010. 

 

• Wu SC and Solaro RJ. Protein kinase c z: A novel regulator of both phosphorylation and de-phosphorylation of cardiac sarcomeric proteins. J Biol Chem 282:30691-30698, 2007. 

 

• Engel PL, Kobayashi T, Biesiadecki B, Davis J, Tikunova S, Wu S, Solaro RJ. Identification of a region of troponin I important in signaling cross-bridge dependent activation of cardiac myofilaments. J Biol Chem 282:183-193, 2007. 

 

• Blaxall BC, Pende A, Wu SC, Port JD. Correlation between intrinsic mRNA stability and the affinity of AUF1 (hnRNP D) and HuR for A+U-rich mRNAs. Mol Cell Biochem 232(1-2):1-11, 2002. 

 

• Bisognano JD, Weinberger, HD, Bohlmeyer TJ, Pende A, Raynolds MV, Sastravaha A, Roden R, Asano K, Blaxall BC, Wu SC, Comunnal C, Singh K, Colucci W, Bristow MR, Port JD. Myocardial-Directed Overexpression of the Human b1-Adrenergic Receptor in Transgenic Mice. J Mol Cell Cardiol 32:817-830, 2000. 

 

• Blaxall BC, Pellett AC, Wu SC, Pende A, Port JD. Purification and Characterization of b-Adrenergic Receptor mRNA-binding Proteins. J Biol Chem 275:4290-4297, 2000.

 

• Hunter S, Burton EA, Wu SC, Anderson SA. Fyn Associates with Cbl and Phosphorylates Tyrosine 731 in Cbl, A Binding Site for Phosphatidylinositol 3-Kinase. J Biol Chem 274:2097-2106, 1999.

 

• Burton EA, Hunter S, Wu SC, Anderson SA.  Binding of src-like Kinases to the β-subunit of the Interleukin-3 Receptor.  J Biol Chem  272:16189-16195, 1997.