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Chastity L. Healy

Assistant Scientist and Lab Manager

Undergraduate degree: B.Sc. in Biology 1999

                                        University of South Dakota

 

Lab Project(s):

1. FFAR4 receptors role in cardiac fibrosis in a mouse model of heart disease.  

2. Making primary cultures of adult mouse myocytes and fibroblasts.

3. Characterizing a new FFAR4 conditional transgenic mouse line.

 

Publications:

  1. Dahl, E.F. Wu, S.C., Healy, C.L. Perry, J. and O'Connell, T.D. ERK mediated survival signaling is dependent on the Gq-G-protein coupled receptor type and subcellular localization in adult cardiac myocytes. J Mol Cell Cardiol 2018. 127: 67-73 PMID: 30528765

  2. Dahl, E.F. Wu, S.C., Healy, C.L. Harsch, B.A., Shearer, G.C., and O'Connell, T.D.  Subcellular compartmentalization of proximal of proximal Gαq-receptor signaling produces unique hypertrophic phenotypes in adult cardiac myocytes.​ J. Biol Chem 2018. 293: 8734-8749 PMID: 30528765

  3. Eclov, JA, Qian Q, Redetke R, Chen Q, Wu SC, Healy C.L., Ortmeier SB, Harmon E, Shearer GC, and O'Connell TD. 2015. EPA, not DHA, prevents fibrosis in pressure overload induced heart failure; potential role of free fatty acid receptor 4. J Lipid Res. PMID: 26435012.​

  4. Wu SC, Dahl EF, Wright CD, Cypher AL, Healy CL, O'Connell TD. 2014. Nuclear localization of α1A-adrenergic receptors is required for signaling in cardiac myocytes: an "inside-out" α1-AR signalin pathway. J Am Heart Assoc. 3(2).

  5. Chen J, Shearer G, Chen Q, Healy CL, Beyer AJ, Gerdes AM, Harris WS, O’Connell TD, and Wang D. 2011. ω-3 fatty acids prevent pressure overload-induced cardiac fibrosis through activation of cGMP/PKG signaling in cardiac fibroblasts. Circulation. 123: 584-93.

  6. Chen Q, Williams R, Healy CL, Wright CD, Wu SC and O’Connell TD. 2010. An association between gene expression and better survival in female mice following myocardial infarction. J. Mol. Cell. Cardiol. 49: 801-811.

  7. Huang Y, Wright CD, Kobayashi S, Healy CL,  Elgethun M, Cypher A, Liang Q, and O’Connell TD. 2008. GATA4 is a survival factor in adult cardiac myocytes, but is not required for α1A-adrenergic receptor survival signaling. Amer. J. Physiol. Heart Circ. Physiol. 295:H699-707.

  8. Wright CD, Chen QH, Baye NL, Huang Y, Merkwan CL, Kasinathan S, and O’Connell TD. 2008. Nuclear α1-adrenergic receptors signal activated ERK localization to caveolae in adult cardiac myocytes. Circ. Res. 103(9):992-1000.  

  9. Huang Y, Wright CD, Merkwan CL, Baye NL, Liang Q, Simpson PC and O’Connell TD. 2007. An α1A-adrenergic-extracellular signal-regulated kinase survival signaling pathway in cardiac myocytes. Circulation. 115: 763-772. 

  10. Percy WH, Brunz JT, Burgers RE, Fromm TH, Merkwan CL, van Dis J. 2001. Inter-relationship between colonic muscularis mucosae activity and changes in transmucosal potential difference. Am J Physiol Gastrointest Liver Physiol. 281(2):G479-89.

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